Microscopic pathology image showing IMPC

Recently, BGI’s scientists published a paper named “Genomic alterations and evolution of cell clusters in metastatic invasive micropapillary carcinoma of the breast” in Nature Communications.

Invasive Micropapillary Carcinoma of Breast (IMPC) is frequently diagnosed at an advanced stage. This tumor is a specific type of invasive ductal carcinoma (or infiltrating carcinoma) of the breast that initially affects the milk ducts and involves other breast parts.

BGI’s researchers performed whole-exome sequencing (WES), whole-genome sequencing (WGS), and topographic cell cluster sequencing (TCCS) techniques to elucidate the genomic mechanisms underlying the highly metastatic and aggressive nature of IMPC.